I'd actually be interested in seeing how things go from the other way around - e.g. taking a photo of a real location and then generating a 256-color or 16-color image for use as a background in a game, with adjustments made as necessary to ensure things like walk paths and item hotspots are of a suitable size. Could be very useful for making fan games, replicating the style & charm of the originals. And I don't expect it would be too technically difficult; AI's involvement would be minimal here, basically just deciding what tweaks to make to the downsampled image, and ensuring stylistic consistency between all the images in an area/game.
Also FWIW I agree with Collector's point about AI & art for existing pieces, though I think these tools are promising for new games, esp. fan stuff like AGI/SCI where most of us simply don't have access to the time/resources/talent required to make a high quality game all by ourselves.
