Maybe it's just me, but I'd go with SCI, hehe.
SCI is so full of features and customizable, it can produce some really outstanding games! You can totally customize the interface and feel of the game.
I've also put tons of work into the tutorials, and though they recommend you know programming before hand, There have been some with absolutely no programming experience who have been able to make games with SCI Studio, and they are looking really nice!
SCI Studio 2.1 creates the complete EGA SCI games with the parser and such. When SCI Studio VGA comes out, you'll be able to use the exact same language, and most of the same code! Just instead of "IF SAID"s, you check which icon was clicked. VGA games should even be easier to program than EGA ones are! Also, VGA games will be so customizable, you will be able to create any interface you like! A King's Quest V popup toolbar, a Leisure Suit Larry 6 bottom control panel, a Lucas Arts SCUMM interface, you name it!
Almost everything you learn in the SCI Studio 2.1 (EGA) tutorial can be applied to SCI Studio VGA, so you will have no trouble switching over!